Luca Guadagnino’s films often focus on people who are in love but shouldn’t be. See his “desire trilogy”—I Am Love (2009), A Bigger Splash (2015), and Call Me by Your Name (2017)—in which a rich wife, a rock star, and a young boy, all in Italy, carry out secret affairs with forbidden men. As Guadagnino recently told Deadline, “To love someone is to find the practice of the possible in the impossible.”

His latest film, Bones and All, is a continuation of the theme—and of his collaboration with Timothée Chalamet. Set in late-1980s America, rather than Guadagnino’s native Italy, the romantic comedy focuses on two young cannibals in love as they road-trip across the country. Starring Chalamet and Taylor Russell, Bones and All premiered at the Venice International Film Festival, where it won the Silver Lion. It hits theaters in the U.S. this coming week. (While you wait, you can catch Salvatore: Shoemaker of Dreams, his documentary about the Italian shoe designer, in theaters now.)