In his first major network role since Grey’s Anatomy, in which he played the heartthrob neurosurgeon dubbed “McDreamy” for 11 seasons, Patrick Dempsey stars as an aging hit man battling early-onset Alzheimer’s. In the show—a remake of the 2003 Belgian film De Zaak Alzheimer (adapted in 2022 into a film starring Liam Neeson)—Dempsey’s existence is split between his personal life as a devoted father and his professional life as a cold-blooded killer. Chaos ensues when the carefully maintained distance between these two worlds narrows. Michael Imperioli is a welcome addition as his friend and handler. —Paulina Prosnitz