Born in Greece, Domḗnikos Theotokópoulos began his career as a traditional Byzantine icon painter. But the man who would become known as El Greco (1541–1614) had loftier ambitions. He headed to Venice, where he befriended the Renaissance icons Titian and Tintoretto, and then went on to Rome, his talent a golden ticket into the pope’s inner circle. After years in Italy, El Greco resettled in Toledo, Spain, where he produced his finest work. “El Greco in the Labyrinth”—Milan’s first comprehensive exhibition on the artist—is thematically organized by the countries in which the artist lived and worked. Don’t miss San Martino and the Beggar, the large-scale canvas of Saint Martin of Tours; it’s coming all the way from the National Gallery, in Washington, D.C. —Elena Clavarino